PEDIATRICS Vol. 56 No. 5 November 1975, pp. 831-834
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Epileptiform Activity in the Electroencephalogram Induced by Lithium Carbonate

Roger A. Brumback M.D.1, Warren A. Weinberg M.D.1, and Barbara L. Herjanic M.D.1

1 Departments of Pediatrics, Neurology, and Psychiatry, St. Louis Children's Hospital, St. Louis, Missouri

Lithium salts have been used in the prophylaxis of manic-depressive disease in adults, in the treatment of episodic behavior disturbances in children, and recently in the treatment of thyrotoxicosis. Side effects of therapy with lithium salts have been frequent at toxic blood levels (1.5 mEq/liter) but rare at therapeutic blood levels (0.8 to 1.5 mEq/liter).

This report describes the development of paroxysmal electroencephalographic abnormalities in a child under treatment with lithium carbonate for a behavior disturbance. Such paroxysmal activity has not been described previously during lithium carbonate therapy.

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CASE REPORT

This white boy was the 2,920-gm product of a normal pregnancy, labor, and repeat Cesarean section delivery in a 39-year-old gravida 2 woman.

[see pdf for figure]




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 J Child NeurolHome page
R. A. Brumback
Warren A. Weinberg (1934--2002)
J Child Neurol, December 1, 2002; 17(12): 916 - 922.
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