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PEDIATRICS Vol. 56 No. 3 September 1975, pp. 487-488
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Other Suggested Mechanisms for Hyperuricemia

Russell W. Chesney M.D.1

1 Division of Biochemical Genetics, and Nephrology McGill University Montreal Children's Hospital Research Institute, 2300 Tupper Street Montreal H3H 1P3, Canada

The article by Mathew and Lifshitz on hyperuricemia calls attention to an important complication which might potentially result in uric acid nephropathy. Hyperuricemia has been noted in several other states of ketosis including ketogenic dietary therapy for convulsive disorders,2 hepatic fructose-i, 6-diphosphatase deficiency,3 and glygen storage disease, type I.4 Five of theents treated with a ketogenis diet developed renal stones.2 All of these entities have in common ketosis and elevated blo lactate and free fatty acid levels; the hyperuricemia is abolished by carbohydrate feeding in all.


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