PEDIATRICS Vol. 56 No. 3 September 1975, pp. 487
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Drs. Goldberg and Spierto Reply

Samuel D. Goldberg M.D.1 and F. W. Spierto Ph.D.1

1 Center for Disease Control, Atlanta, Georgia 30333

In a previous publication from this laboratory, we acknowledged the variatioplasma renin activity (PRA) with posture, diurnal variation, and salt intake. Dr. John Laragh's group has related PRA to 24-hour urinary sodium excret. However, we felt and continue to feel this method is iractical in any setting other than a metabolic ward and, therefore, developed the method relating PRA and sodium/creatinine ratio in a urine specimen collected immediatelyafter venipuncture in adults. Admittedly, in dealindiately ividuals not of adult size, as is the case in our studies of adolescents, relationship of PRA to sodium/creatinine ratio per unit surface area would be of great interest.