PEDIATRICS Vol. 56 No. 3 September 1975, pp. 380-387
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Long-Term Follow-up for Immunity After Monovalent or Combined Live Measles, Mumps, and Rubella Virus Vaccines

Robert E. Weibel M.D.1, Eugene B. Buynak Ph.D.1, Arlene A. McLean M.S.1, and Maurice R. Hilleman Ph.D., D.Sc.1

1 Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, and the Division of Virus and Cell Biology Research, Merck Institute for Therapeutic Research, West Point, Pennsylvania

Antibody in human subjects persisted without substantial decline for 8 years after mumps vaccine (Jeryl Lynn), for 6 years after measles (Attenuvax), for 5frac12 years after rubella vaccine (HPV-77 duck), for 5 years after measles-mumps-rubella and mumps-rubella combined vaccines, for 4 years after measles and rubella, and for 2 years after measles-mumps vaccines, the longest periods tested. Protective immunity against mumps illness persisted through the eighth year. The patterns for antibody following vaccination parallel those for natural infection and indicate that immunity will be lasting. Subclinical reinfection evidenced by antibody increase was commonly seen in persons who had been vaccinated, much as follows the natural infection.

Submitted on October 3, 1974
Accepted on December 19, 1974




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