PEDIATRICS Vol. 56 No. 1 July 1975, pp. 119-121
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Effects of Thyrotropin-Releasing Hormone in Minimal Brain Dysfunction

C. M. Tiwary M.B.B.S., M.R.C.P., D.C.H.1, A. L. Rosenbloom M.D.2, M. F. Robertson M.A.2, and J. C. Parker B.S., P.E.2

1 Department of Pediatrics, University of Nebraska Medical Center 42nd and Dewey Avenue, Omaha, Nebraska 68105
2 Departments of Pediatrics and Child Psychiatry, University of Florida College of Medicine Gainesville, Florida

Synthetic thyrotropin-releasing hormone (TRH) has effected mood elevation in depressed patients and calmed labile behavior in a retarded adolescent. The present study was conducted to determine the effect of TRH in two children of normal intelligence with minimal brain dysfunction (hyperkinetic impulse disorder).

MATERIALS AND METHODS

Two 6 1.2year-old unrelated Caucasian subjects, a boy and a girl, were included in the double-blind cross-over study. Both were in good physical health and had unremarkable perinatal histories. Motor development and intelligence quotient were normal in both children, but the boy had delayed speech.