PEDIATRICS Vol. 55 No. 6 June 1975, pp. 888-889
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Fetal Addiction to Pentazocine

Arthur E. Kopelman M.D.1

1 University of Rochester School of Medicine and Dentistry 260 Crittenden Boulevard, Rochester, New York 14642

A case of neonatal withdrawal symptoms following maternal use of pentazocine was recently reported.1 This is the report of a second case with severe withdrawal symptoms which were successfully treated with phenobarbital.

CASE REPORT

A 2,180-gm, small-for-date, black female infant was delivered by cesarean section at 37 weeks' gestation. The mother, a 26-year-old gravida 3, para 0 woman with sickle cell anemia, had several painful sickle cell crises, congestive heart failure, pneumonia, and a urinary tract infection during this pregnancy. The two previous pregnancies had ended in abortion. In the second half of this pregnancy, she was treated with frequent packed-cell transfusions in order to decrease to less than 50% the number of her erythrocytes with sickle hemoglobin and hence the risk of clinical sickling.