PEDIATRICS Vol. 55 No. 6 June 1975, pp. 802-806
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Subcutaneous Calcium Deposition in the Neonate Associated With Intravenous Administration of Calcium Gluconate

Rajam S. Ramamurthy M.D.1, Vivian Harris M.D.1, and Rosita S. Pildes M.D.1

1 Division of Neonatology and Pediatric Radiology, Cook County Hospital, the University of Health Sciences/Chicago Medical School, and the Abraham Lincoln School of Medicine of the University of Illinois, Chicago

Nine infants who had severe local manifestations following intravenous administration of calcium gluconate are presented. The lesions appeared at the intravenous sites as firm subcutaneous nodules or areas of inflammation with central softening and fluctuation. The interval between appearance of the lesion and calcium administration was 13 ± 2.5 (mean ± SEM) days. Five infants were treated with antibiotics and three of the five had incision and drainage. Roentgenographic evidence of subcutaneous calcification was seen in all cases at the time the lesions were first noticed. In two infants the entire cephalic vein was calcified. Induration and inflammation completely subsided in six infants, four of whom had follow-up roentgenograms showing complete resolution of calcification. A conservative approach in management is recommended.

Submitted on May 20, 1974
Accepted on October 2, 1974




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