PEDIATRICS Vol. 55 No. 6 June 1975, pp. 751-753
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Present status of the prevention of neural tube defects

Henry L. Nadler M.D.1

1 Children's Memorial Hospital, and Department of Pediatrics, Northwestern University School of Medicine Chicago, Illinois 60614

During the past two decades, a number of dramatic changes have taken place in the treatment of infants born with myelomenmgocele. Since the development in the 1950's and early 1960's of more effective methods for treating hydrocephalus, urinary incontinence, and paraplegia, aggressive treatment regimes have been initiated. Numerous articles and editorials have questioned these various treatment modalities based on the lack of objective long-term studies documenting their effectiveness. More recently, dissatisfaction with the results of current surgical prodecures for children with myelomeningocele has led to the development of selective criteria for early treatment.1,2

The purpose of this commentary, however, is not to discuss the merits of selective treatment for myelomeningocele but rather to discuss some of the recent developments for the prevention of this disorder.