PEDIATRICS Vol. 55 No. 5 May 1975, pp. 604-613
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rigatto, H.
Right arrow Articles by de la Torre Verduzco, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rigatto, H.
Right arrow Articles by de la Torre Verduzco, R.

Chemoreceptor Reflexes in Preterm Infants: I. The Effect of Gestational and Postnatal Age on the Ventilatory Response to Inhalation of 100% and 15% Oxygen

Henrique Rigatto M.D.1, June P. Brady M.B., B.Chir.1, and Rafael de la Torre Verduzco M.D.1

1 Department of Pediatrics, University of Manitoba, Winnipeg, Canada, and the Department of Pediatrics and the Cardiovascular Research, Institute, University of California, San Francisco

We studied 16 "healthy" preterm infants (birthweight, 1,000 to 2,000 gm) 94 times during postnatal life to define the effect of gestational and postnatal age on the ventilatory response to 100% and 15% oxygen. They were given air, then 100% oxygen for two and five minutes respectively (No. = 63) or 21%, 15%, and then 21% oxygen for five minutes each (No. = 31). We measured respiratory minute and tidal volumes, frequency, heart rate, and alveolar Pco2 and Po2. We used the magnitude of the immediate change in ventilation during 100% and 15% oxygen breathing to test peripheral chemoreceptor function. The immediate decrease in ventilation with 100% oxygen and the immediate increase in ventilation with 15% oxygen were statistically similar at different gestational and postnatal ages. The late increase in ventilation (five minutes) with 100% oxygen was also similar at different ages. However, the late decrease in ventilation with 15% oxygen was not present at 18 days of age. These findings suggest that: (1) the peripheral chemoreceptors are active at least from 28 weeks of gestation and are probably not important in triggering periodic breathing or apnea in preterm infants; and (2) the preterm infant matures his response to hypoxia and is able to sustain hyperventilation with low oxygen by 18 days of age.

Submitted on July 22, 1974
Accepted on October 14, 1974




This article has been cited by other articles:


Home page
 Integr. Comp. Biol.Home page
R. W. Bavis, F. L. Powell, A. Bradford, C. C.W. Hsia, J. E. Peltonen, J. Soliz, B. Zeis, E. K. Fergusson, Z. Fu, M. Gassmann, et al.
Respiratory plasticity in response to changes in oxygen supply and demand
Integr. Comp. Biol., October 1, 2007; 47(4): 532 - 551.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
F. Lofaso, S. Dauger, B. Matrot, G. Vardon, C. Gaultier, and J. Gallego
Inhibitory effects of repeated hyperoxia on breathing in newborn mice
Eur. Respir. J., January 1, 2007; 29(1): 18 - 24.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
N. Ramanantsoa, V. Vaubourg, S. Dauger, B. Matrot, G. Vardon, Z. Chettouh, C. Gaultier, C. Goridis, and J. Gallego
Ventilatory response to hyperoxia in newborn mice heterozygous for the transcription factor Phox2b
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2006; 290(6): R1691 - R1696.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
M. H. Wilkinson, K.-L. Sia, E. M. Skuza, V. Brodecky, and P. J. Berger
Impact of changes in inspired oxygen and carbon dioxide on respiratory instability in the lamb
J Appl Physiol, February 1, 2005; 98(2): 437 - 446.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. A. Wong, A. Bano, A. Rigaux, B. Wang, B. Bharadwaj, S. Schurch, F. Green, J. E. Remmers, and S. U. Hasan
Pulmonary vagal innervation is required to establish adequate alveolar ventilation in the newborn lamb
J Appl Physiol, September 1, 1998; 85(3): 849 - 859.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
R. Tessier, M. Cristo, S. Velez, M. Giron, J. G. Ruiz-Palaez, Y. Charpak, and N. Charpak
Kangaroo Mother Care and the Bonding Hypothesis
Pediatrics, August 1, 1998; 102(2): e17 - 17.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
J. M. Ramirez, U.J.A. Quellmalz, and B. Wilken
Developmental Changes in the Hypoxic Response of the Hypoglossus Respiratory Motor Output In Vitro
J Neurophysiol, July 1, 1997; 78(1): 383 - 392.
[Abstract] [Full Text] [PDF]