PEDIATRICS Vol. 55 No. 4 April 1975, pp. 474-478
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The Pathology of Neonatal Osteomyelitis

John A. Ogden M.D.1 and George Lister M.D.1

1 Section of Orthopedics and Human Growth and Development Study Unit, and the Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut

The examination of multiple bones from a child who died of complications of septicemia and osteomyelitis elucidated the pathologic processes of infantile osteomyelitis. From a metaphyseal focus, there is spread in several directions. Most important, the infection can spread across the growth plate, along transphyseal vessels, to penetrate the epiphysis. Areas of direct destruction of growth plate were frequent findings, and allowed another route into the epiphysis.




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