PEDIATRICS Vol. 55 No. 3 March 1975, pp. 376-387
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Acute Necrotizing Enterocolitis in Infancy: A Review of 64 Cases

Thomas V. Santulli M.D.1, John N. Schullinger M.D.1, William C. Heird M.D.1, Robert D. Gongaware M.D.1, Joachim Wigger M.D.1, Barbara Barlow M.D.1, William A. Blanc M.D.1, and Walter E. Berdon M.D.1

1 Departments of Surgery, Pediatrics, Pathology, and Radiology, College of Physicians and Surgeons, Columbia University, and the Surgical Service of Babies Hospital, The Children's Medical and Surgical Center, Columbia-Presbyterian Medical Center, New York

Sixty-four cases of necrotizing enterocolitis are reviewed. The diagnosis was based on tissue examination in 57 and on the clinical syndrome, including pneumatosis, in 7. Three factors are important in the development of the disease: injury to the intestinal mucosa, bacteria, and feedings. The indications for surgical intervention are pneumoperitoneum, signs of peritonitis, and intestinal obstruction. The importance of stress in the etiology of the disease is confirmed by the high incidence of perinatal complications, particularly hypoxia. The mortality was high, but results are improving with the institution of early aggressive treatment.

Submitted on April 29, 1974
Accepted on August 9, 1974




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