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I would state that in the past six years, during which my practice has been confined to pediatric gastroenterology, I have not had the opportunity to treat a single patient with acrodermatitis enteropathica. I agree that the halogenated hydroxyquinolines are the drug of choice for this condition. It may be of interest that approximately 15% of all my new referrals are infants or school-age children with irritable colon syndrome as described by Murray Davidson and others.