PEDIATRICS Vol. 55 No. 1 January 1975, pp. 75-82
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wilmshurst, E. G.
Right arrow Articles by Gleason, R. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wilmshurst, E. G.
Right arrow Articles by Gleason, R. E.

Endogenous and Exogenous Insulin Responses in Patients With Cystic Fibrosis

Errol G. Wilmshurst 1, J. Stuart Soeldner 1, Douglas S. Holsclaw 1, Robert L. Kaufmann 1, Harry Shwachman 1, Thomas T. Aoki 1, and Ray E. Gleason 1

1 Elliott P. Joslin Research Laboratory, Department of Medicine, Peter Bent Brigham Hospital, and the Children's Hospital Medical Center, Harvard Medical School, and New England Deaconess Hospital, Boston

Eight male patients with cystic fibrosis, normal nutrition, normal physical activity, relatively mild pulmonary disease, no evidence of liver disease and no family history of diabetes mellitus underwent a series of carbohydrate tolerance tests in comparison with a group of 18 normal male subjects matched for age and body weight.

Compared with the normal group, the patients with cystic fibrosis had significantly impaired glucose tolerance and significantly lower serum immunoreactive insulin levels during oral and intravenous glucose tolerance tests; serum insulin levels were also significantly lower after intravenous administration of tolbutamide in the patients with cystic fibrosis, but the reduction in blood glucose concentration in each group was not significantly different. During an intravenous insulin test, the decrease in blood glucose concentration was the same for both groups, in spite of significantly lower serum insulin levels in the patients with cystic fibrosis. The percentage fall in plasma free fatty acids was at least as great in the patients with cystic fibrosis as in normals during the test procedures, while a significant decrease in plasma alpha-amino nitrogen after intravenously administered insulin was seen only in the patients with cystic fibrosis.

These studies suggest that the carbohydrate intolerance of cystic fibrosis is consequent upon an impaired insulin response to glucose, but that this insulin deficiency is partly compensated for by increased peripheral tissue sensitivity to insulin.

Submitted on January 2, 1974
Accepted on March 20, 1974




This article has been cited by other articles:


Home page
 Am. J. Clin. Nutr.Home page
V. Figueroa, C. Milla, E. J Parks, S. J. Schwarzenberg, and A. Moran
Abnormal lipid concentrations in cystic fibrosis
Am. J. Clinical Nutrition, June 1, 2002; 75(6): 1005 - 1011.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
D. S. Hardin, A. LeBlanc, S. Lukenbaugh, L. Para, and D. K. Seilheimer
Proteolysis Associated With Insulin Resistance in Cystic Fibrosis
Pediatrics, March 1, 1998; 101(3): 433 - 437.
[Abstract] [Full Text] [PDF]

Home page
 CLIN PEDIATRHome page
T. Pfeifer
Diabetes in Cystic Fibrosis
Clinical Pediatrics, November 1, 1992; 31(11): 682 - 687.
[PDF]