PEDIATRICS Vol. 55 No. 1 January 1975, pp. 44-50
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Oxygen Plus Pressure Plus Time: The Etiology of Bronchopulmonary Dysplasia

Alistair G. S. Philip M.B., M.R.C.P.(E.), D.C.H1

1 Kauikeolani Children's Hospital and the Department of Pediatrics, University of Hawaii, Honolulu

Ten infants developed the chronic pulmonary syndrome designated bronchopulmonary dysplasia, following artificial (assisted) ventilation using a volume-regulated positive-pressure respirator. Despite previous reports implicating elevated oxygen concentrations for prolonged periods of time, only two infants required more than 80% oxygen for more than 24 hours, and only one infant required 60% oxygen for more than 100 hours. "Immature" lungs when exposed to inspired oxygen concentrations over 40% for as little as three days via positive-pressure ventilation may develop bronchopulmonary dysplasia. The role of the underlying disease and the relationship with Wilson-Mikity syndrome remain uncertain.

Submitted on May 16, 1974
Accepted on August 7, 1974




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