PEDIATRICS Vol. 55 No. 1 January 1975, pp. 101-108
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Pharmaceutic Factors Affecting Pediatric Compliance

Mary E. Mattar M.D.1, James Markello M.D.1, and Sumner J. Yaffe M.D.1

1 Department of Pediatrics, School of Medicine, State University of New York at Buffalo, and the Division of Pharmacology, Children's Hospital, Buffalo, New York

Evaluation of treatment given at home was studied in children with otitis media who were seen in an outpatient clinic. Full compliance was present in only 5% of the initial 100 patients (Study A). Practical factors limiting their compliance included inadequate dispensing of medication at drug stores, 15%; incorrect therapy schedule, 36%; early termination, 37%; spilled medicine, 7%; therapy shared, 5%. Because of these findings, a plan was implemented (Study B) in which hospital pharmacy personnel gave patient families verbal and written instructions for administering medications that were dispensed, together with a calibrated measuring device and a calendar to record doses taken. Full coiiipliance was raised to 51% in this pilot group (of 33 patients) as compared with 8.5% in 200 concurrent controls who went to neighborhood drug stores.

The importance of detailed therapy instructions is stressed. The potential role of the pharmacist in improving compliance is demonstrated.

Submitted on February 18, 1974
Accepted on April 23, 1974




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