PEDIATRICS Vol. 54 No. 5 November 1974, pp. 599-602
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Gastrin Response to Calcium Infusion: An Aid to the Improved Diagnosis of Zollinger-Ellison Syndrome in Children

David L. Schwartz M.D.1, John J. White M.D., C.M.1, Frank Saulsbury M.D.1, and J. Alex Haller Jr. M.D.1

1 Division of Pediatric Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland

Serum gastrin levels were equivocally elevated in a 9-year-old boy with suspected Zollinger-Ellison syndrome. He had copious hyperacidity on fasting gastric analysis which was increased insignificantly following histamine administration. A calcium infusion test produced diagnostically elevated serum gastrin values (average 400 pg/ml) which were sustained for the course of the four-hour infusion. A malignant islet cell tumor of the pancreas metastatic to a celiac lymph node was found, and total gastrectomy performed. The boy adjusted well and is gaining along his curves for height and weight one year postoperatively. The calcium infusion test, or its counterpart the calcium challenge, appears to be a helpful method for identifying the Zollinger-Ellison syndrome, particularly in children in whom fasting serum gastrin values may not be diagnostic by adult standards.