PEDIATRICS Vol. 54 No. 5 November 1974, pp. 547-552
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A 16-Year Follow-up Study of 163 Children with Nephrotic Syndrome

M. William Schwartz M.D.1, George J. Schwartz M.D.1, and David Cornfeld M.D.1

1 Renal Service, Children's Hospital of Philadelphia, and Department of Pediatrics, School of Medicine, University of Pennsylvania, Philadelphia

One hundred and sixty-three children with onset of nephrotic syndrome prior to 1959 are the subjects of this study. The average duration of follow-up was 16.5 years with 79% (129) being followed 15 years. The Life Table survival rate was 77% at 15 years. There were no correlations between the survival rate and the age of onset or sex of the patient. Hypertension in combination with azotemia, and/or hematuria was associated with a poorer prognosis. Twenty percent of the children showed a nonrelapsing course after the first year, whereas 45% experienced several relapses before achieving apparent cure. Ten percent had continued activity. Seventy-nine percent of the patients who were initially resistant to steroid therapy were dead at the 15-year follow-up.

Submitted on February 20, 1974
Accepted on June 13, 1974