PEDIATRICS Vol. 54 No. 4 October 1974, pp. 508-511
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rieger, C. H. L.
Right arrow Articles by Rothberg, R. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rieger, C. H. L.
Right arrow Articles by Rothberg, R. M.

Correction of Neutropenia Associated With Dysgammaglobulinemia

Christian H. L. Rieger M.D.1, John W. Moohr M.D.1, and Richard M. Rothberg M.D.1

1 Department of Pediatrics, University of Chicago, Chicago, Illinois

Dysgammaglobulinemia type I (deficiency of IgG and IgA with normal or elevated IgM) is frequently associated with severe neutropenia, undue susceptibility to infection and recurrent or persistent mouth ulcers.1 The mechanism underlying the neutropenia is unclear and gamma-globulin treatment has in all but two cases2,3 failed to increase absolute neutrophil counts. This report describes the correction of severe neutropenia in a patient with dysgammaglobulinemia type I after administration of unusually high doses of gamma-globulin. It is shown that treatment is only effective if serum IgG levels are maintained above the level necessary to keep individuals with hypogammaglobulinemia and normal neutrophil counts free of infection.