PEDIATRICS Vol. 54 No. 4 October 1974, pp. 492
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TRANSPLACENTAL CARCINOGENESIS

Robert W. Miller M.D.1

1 Epidemiology Branch, National Cancer Institute-NIH, Bethesda, Maryland

An overview of experimental studies concerning transplacental chemical carcinogenesis and their possible implications for man has been published by J. M. Rice (Teratology, 8:113, 1973).

Ulfelder (Amer. J. Obstet. Gynec., 17:794, 1973) believes that there may have been 10,000 to 16,000 persons exposed in utero to diethylstilbestrol, 1960 to 1970. He estimates the probability of developing adenosis or other minor morphologic anomalies in girls at not less than 30%, and guesses the risk of adenocarcinoma of the cervix or vagina to be about one in 1,000. A more precise estimate from a prospective study at the Mayo Clinic is less than seven per 1,000 by age 13 and less than 13 per 1,000 by age 22 (Lanier, A. P., et al., Mayo Chin. Proc., 48:793, 1973).