PEDIATRICS Vol. 54 No. 4 October 1974, pp. 470-475
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Serum LH and FSH Responses to Synthetic LH-RH in Normal Infants, Children and Patients With Turner's Syndrome

Selzo Suwa M.D.1, Hatae Maesaka M.D.1, and Ichiro Matsui M.D.1

1 Section of Endocrinology and Metabolism, and Section of Cytogenesis, Department of Pediatrics, Kanagawa Children's Medical Center, Yokohama, Japan

Effects of LH-RH on LH and FSH release were studied in 26 normal children and six patients with Turner's syndrome (two of them showed 45 x karyotype and the others were mosaics). Synthetic LH-RH (2µg/kg of body weight) was given intramuscularly after an overnight fast.

The increase of serum FSH level was significantly greater in normal female infants than male infants. A similar tendency was observed in normal female children aged 2 to 9 years. No sex difference was observed in the LH response to LH-RH in all the normal subjects Studied. The response of FSH release to LH-RH was significantly greater than that of LH in female infants and young female children. The responsiveness of LH to LH-RH gradually increased with advancing age.

Basal serum levels of FSH rather than LH were high in the patients with Turner's syndrome. Again a much greater increase of serum FSH than of LH was noted after the administration of LH-RH to patients with Turner's syndrome.

Submitted on July 30, 1973
Accepted on October 25, 1973