PEDIATRICS Vol. 54 No. 4 October 1974, pp. 456-460
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Griscom, N. T.
Right arrow Articles by Mackie, G. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Griscom, N. T.
Right arrow Articles by Mackie, G. G.

Gastric Antral Narrowing in Chronic Granulomatous Disease of Childhood

N. Thorne Griscom M.D.1, John A. Kirkpatrick Jr. M.D.1, Bertram R. Girdany M.D.1, Walter E. Berdon M.D.1, Richard J. Grand M.D.1, and G. Gary Mackie M.D.1

1 Departments of Radiology of Harvard Medical School, Children's Hospital Medical Center (Boston), Temple University Medical School, St. Christopher's Hospital for Children (Philadelphia), University of Pittsburgh Medical School, Children's Hospital of Pittsburgh, College of Physicians and Surgeons, and Babies Hospital (New York); from the Departments of Pediatrics of Harvard Medical School and Children's Hospital Medical Center (Boston); and the Department of Surgery, Children's Hospital Medical Center (Boston)

Five boys, examined because of continued vomiting, were found to have a peculiar annular narrowing of the lumen of the gastric antrum. The roentgenographic appearance was almost uniform from case to case. The narrowing in all four cases examined histologically was caused by gross thickening of the antral wall by local granuloma formation.

Four boys were later shown to have chronic granulomatous disease of childhood; the unoperated child was already known to be suffering from this disease. In one child the granulomatous narrowing of the antrum was the first manifestation of the disease. Crohn's disease of the antrum, peptic ulcerative disease, eosinophilic granuloma, and eosinophilic gastritis had been considered in these cases before the correct diagnosis was made.

The nitro-blue tetrazolium (NBT) test should be used in obscure lesions of the antrum, especially when there is annular narrowing of that structure in boys. In children with chronic granulomatous disease and antral narrowing, proper antibiotic therapy may make surgical intervention unnecessary,

Submitted on August 9, 1973
Accepted on September 13, 1973




This article has been cited by other articles:


Home page
 RadioGraphicsHome page
G. Khanna, S. C. Kao, P. Kirby, and Y. Sato
Imaging of Chronic Granulomatous Disease in Children
RadioGraphics, September 1, 2005; 25(5): 1183 - 1195.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
B. E. Marciano, S. D. Rosenzweig, D. E. Kleiner, V. L. Anderson, D. N. Darnell, S. Anaya-O'Brien, D. M. Hilligoss, H. L. Malech, J. I. Gallin, and S. M. Holland
Gastrointestinal Involvement in Chronic Granulomatous Disease
Pediatrics, August 1, 2004; 114(2): 462 - 468.
[Abstract] [Full Text] [PDF]

Home page
 CLIN PEDIATRHome page
L. L. Barton, S. L. Moussa, R. G. Villar, and R. L. Hulett
Gastrointestinal Complications of Chronic Granulomatous Disease: Case Report and Literature Review
Clinical Pediatrics, April 1, 1998; 37(4): 231 - 236.
[Abstract] [PDF]