PEDIATRICS Vol. 54 No. 4 October 1974, pp. 455
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Reticulum cell sarcoma of the brain with Wiskott-Aldrich syndrome

Robert W. Miller M.D.1

1 Epidemiology Branch, National Cancer Institute—NIH, Bethesda, Maryland

Congenital immunodeficiency predisposes patients with Wiskott-Aldrich syndrome to lymphoreticular neoplasia. A 19-year-old boy with the syndrome has recently been reported with reticulum cell sarcoma confined to the brain, a very rare site for this neoplasm (Heidelberger, K. P., and LoGolvan, D. P., Cancer, 33:281-284, 1974). The same rare neoplasm has been observed in 13 renal-transplant recipients on immunosuppressive therapy (Hoover, R. N., and Fraumeni, J. F., Jr., Lancet, II:55, 1973). The patient with Wiskott-Aldrich syndrome and reticulum cell sarcoma of the brain, unlike those with ataxia-telangiectasia and lymphoma, experienced no adverse reaction to radiotherapy or chemotherapy.