PEDIATRICS Vol. 54 No. 4 October 1974, pp. 438-441
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Lead Neuropathy and Sickle Cell Disease

Gerald Erenberg M.D.1, Steven S. Rinsler M.D.1, and Bernard G. Fish M.D.1

1 Departments of Neurology, Pediatric Neurology Section and Pediatrics, Montefiore Hospital and Medical Center and Albert Einstein College of Medicine, Bronx, New York

Four cases of lead neuropathy in children with hemoglobin S-S or S-C disease are reported. Neuropathy is a rare manifestation of lead poisoning in children, and only ten other cases have been well documented in the pediatric literature. The last previous case report of lead neuropathy was also in a child with hemoglobin S-S disease. The neuropathy seen in the children with sickle cell disease was clinically similar to that seen in the previously reported cases in nonsicklers, but differed in both groups from that usually seen in adult cases. It is, therefore, postulated that children with sickle cell disease have an increased risk of developing neuropathy with exposure to lead. The exact mechanism for this association remains unknown, but in children with sickle cell disease presenting with symptoms or signs of peripheral weakness, the possibility of lead poisoning must be considered.

Submitted on December 12, 1973
Accepted on March 15, 1974




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S. M. Selbst, F. M. Henretig, and J. Pearce
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Clinical Pediatrics, May 1, 1985; 24(5): 280 - 285.
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