PEDIATRICS Vol. 54 No. 3 September 1974, pp. 366-369
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Pseudohermaphroditism, Nephron Disorder and Wilms' Tumor: A Unifying Concept

Amin Y. Barakat M.D.1, Zoe L. Papadopoulou M.D.1, Roma S. Chandra M.D.1, Charles E. Hollerman M.D.1, and Philip L. Calcagno M.D.1

1 Department of Pediatrics Georgetown University, and Department of Pathology George Washington University School of Medicine Washington, D.C.

We have observed three infants and learned of two other previously unreported cases presenting with various combinations of pseudohermaphroditism, Wilms' tumor and nephron disorders including nephrotic syndrome. The concurrence of these disorders, as described in our cases and others from the literature, indicates that they may have teratogenic origins in common and that all of them originate when pseudohermaphroditism does; namely, during embryogenesis.




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