PEDIATRICS Vol. 54 No. 1 July 1974, pp. 81-83
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pittman, F. E.
Right arrow Articles by Westphal, M. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pittman, F. E.
Right arrow Articles by Westphal, M. C.

Optic Atrophy Following Treatment With Diiodohydroxyquin

Fred E. Pittman M.D., Ph.D.1 and Milton C. Westphal M. D.1

1 Department of Medicine, Gastroenterology Division, and Department of Pediatrics, Medical University of South Carolina, and the Veterans Administration Hospital, Charleston, South Carolina

Permanent severe bilateral optic atrophy was detected in a 3frac12-year-old white child with an unusual type of colitis following oral administration of diiodohydroxyquin, 1,950 mg daily for eight weeks, given as nonspecific treatment of diarrhea. Neurological examination four weeks after the appearance of partial blindness revealed no abnormalities other than optic atrophy. Examination three years later showed persistence of the optic atrophy and the presence of nystagmus on extreme lateral gaze. Because of strong evidence suggesting dose-related neurotoxicity associated with use of the chemically similar drug, iodochlorhydroxyquin, it was thought that this child's optic atrophy was caused by the large amount of diiodohydroxyquin he received. The presence of active inflammatory bowel disease in association with pharmacologically delayed colonic emptying may have enhanced colonic absorption of the drug, thereby contributing to its neurotoxicity.

Submitted on September 12, 1973
Accepted on December 9, 1973




This article has been cited by other articles:


Home page
 ScienceHome page
C. Eckhert, M. Sloan, Duncan JR, and L. Hurley
Zinc binding: a difference between human and bovine milk
Science, February 25, 1977; 195(4280): 789 - 790.
[Abstract] [PDF]