PEDIATRICS Vol. 54 No. 1 July 1974, pp. 51-55
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Plasma vitamin A and E Levels in Children With Familial Type II Hyperlipoproteinemia During Therapy With Diet and Cholestyramine Resin

C. J. Glueck M.D.1, R. C. Tsang M.B.B.S.1, R. W. Fallat M.D.1, and D. Scheel B.A.1

1 Departments of Medicine and Pediatrics, Lipoprotein Research Laboratory and General Clinical Research Center, Cincinnati General Hospital, Fels Division of Pediatrics and Newborn Division, Children's Hospital Research Foundation, University of Cincinnati, College of Medicine, Cincinnati, Ohio

Effects of a low cholesterol (<300 mg/day), polyunsaturate-rich (P:S 1.5/1) diet and cholestyramine resin (12 gm active resin per day) on plasma vitamin A and E levels were studied in 46 children with familial type II hyperlipoproteinemia. On diet alone (for four to six months), vitatmin A and E levels were higher in children with familial type II than in normal control children (p<.0l). Thirty of the 46 children with familial type II did not normalize cholesterol and beta-lipoprotein (LDL) cholesterol on diet alone, and were followed subsequently on diet with additional cholestyramine resin (12 gm/day) for six months. Despite lowering of LDL on diet and cholestyramine resin, vitamin A and E levels remained higher in children with familial type II than in normal controls (p<.0l). Our short-term experience suggests that neither diet nor cholestyramine resin represents any immediate threat to maintenance of adequate vitamin A and E levels in children with familial hypercholesterolemia who have supranormal levels of these fat-soluble vitamins and LDL prior to and during treatment.

Submitted on December 5, 1973
Accepted on February 4, 1974




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