PEDIATRICS Vol. 54 No. 1 July 1974, pp. 121
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Letter to the Editor

Sue McIntosh M.D.1 and Gregg T. Aspnes M.D.1

1 Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510

It is becoming increasingly apparent, as Dr. Muriel and others have observed, that transient encephalopathy often occurs in leukemic children during the second month following prophylactic irradiation. We have found in retrospect that this "reactive syndrome" occurs to a variable degree in at least 30 percent of patients, some of whom are well again after only a few days of mild somnolence and malaise.

We agree that these types of delayed encephalopathy are different in many ways from acute effects of intrathecal methotrexate.