PEDIATRICS Vol. 53 No. 6 June 1974, pp. 950-951
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The Role of a Dialyzable Serum Factor in the Increased O2 Affinity of Hemoglobin in the Red Cells of Hypoxic Newborns

Domokos Boda M.D.1, László Murányi M.D.1, Erna Eck Ph.D.1, and Magda Szilágyi 1

1 Pediatric Department, University Medical School, Szeged, Hungary 6725

Attempts to treat infants with neonatal adaptation disturbance by improving the O2 transport function of their blood with exchange transfusion are significant. Oski, in his recent E. Mead Johnson Award Address, noted that the exchange transfusion, in addition to influencing the fetal hemoglobin and 2, 3-DPG concentration in the red cells, alters many other factors that have been claimed to modify both morbidity and mortality in these infants. He said, "Among these factors are included the serum albumin level, blood coagulation factors and the presence of unidentified, but dialyzable toxins."

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