PEDIATRICS Vol. 53 No. 6 June 1974, pp. 913-919
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The Electron Microscopic Appearance of Presecreted Gastric Mucus in Cystic Fibrosis

Clinton B. Lillibridge M.D.1, Marilyn R. Brown M.D.1, and Janet G. Hall 1

1 Department of Pediatrics, University of Rochester School of Medicine and Dentistry, and the Isaac Gordon Center for Gastrointestinal Diseases, The Genesee Hospital, Rochester, New York

Gastric mucosal biopsies from eight new untreated patients with cystic fibrosis (CF) and two normal subjects were studied by quantitative techniques of electron microscopy (EM) to determine whether presecreted gastric mucus was more compact (viscid) than normal. Analysis of variance techniques show no differences between means of all groups studied. These observations suggest that mucus may not be viscid prior to secretion. Electron microscopy of gastric mucus does not appear to be of diagnostic value in CF.

Submitted on July 19, 1973
Accepted on December 20, 1973