PEDIATRICS Vol. 53 No. 4 April 1974, pp. 458-470
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Cholesterol at Birth and Age 1: Comparison of Normal and Hypercholesterolemic Neonates

Reginald C. Tsang M.B., B.S.1, Ronald W. Fallat M.D.1, and Charles J. Glueck M.D.1

1 Fels Division of Pediatric Research and Newborn Division, Departments of Pediatrics, Obstetrics and Gynecology, and Medicine, the Children's Hospital Research Foundation, The Lipoprotein Research Laboratory and General Clinical Research Center, University of Cincinnati School of Medicine

Plasma cholesterol was evaluated at birth and at age 1 in 56 infants who had elevated cord blood cholesterol levels, and in 42 infants who had normal cord blood cholesterol levels. Both groups of infants came from a study of 1,800 unselected live births. Familial hypercholesterolemia was documented by three-generation transmission (from grandparent to parent to neonate) or by presence of tendinous xanthomatosis with hyper-beta-lipoproteinemia in eight neonates and kindreds. A minimal estimate of the heterozygote frequency of familial hyperlipidemia in unselected live births was 0.44% (8/1,800). On moderate-high cholesterol intake at age 1, three of four infants with familial hypercholesterolemia maintained distinctive elevations of plasma cholesterol. On low cholesterol diets, the distinction between four infants with familial hypercholesterolemia and normal or other hypercholesterolemic infants was blurred. Responsiveness to low cholesterol diet may hold promise in a long-term approach to normalization of plasma cholesterol in infants with familial hypercholesterolemia.

Submitted on February 9, 1973
Accepted on November 1, 1973




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