PEDIATRICS Vol. 53 No. 3 March 1974, pp. 330-335
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Infectious Mononucleosis and Epstein Barr Virus in Childhood

Dov Tamir M.D.1, Abraham Benderly M.D.1, Joseph Levy M.D.1, Edna Ben-Porath Ph.D.1, and Ami Vonsover M.Sc.1

1 Department of Pediatrics "A" and Department of Microbiology, Rambam University Hospital and the Abba Khoushi School of Medicine, Haifa, Israel

The Epstein-Barr virus (EBV) antibody titer was examined in 22 children whose atypical mononuclear cells appeared in the peripheral blood smear. Paul-Bunnell and mononucleosis tests were negative in all these children, but antibodies to EBV were demonstrated in 21 of them. Only five children in a control group of 27 had antibodies to EBV. We conclude that the presence of EBV antibodies with a rising titer supports a diagnosis of infectious mononucleosis. It is of particular importance in children under 1 year of age in whom the finding of atypical mononuclear cells in the absence of positive Paul-Bunnell and mononucleosis tests shows a strong correlation with EBV antibody titer. This finding frequently occurs in the absence of typical clinical features of infectious mononucleosis.

Submitted on June 26, 1972
Accepted on September 7, 1973




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