PEDIATRICS Vol. 53 No. 2 February 1974, pp. 273-275
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Vitamin K1 Content of Infant Formula Products

Donald L. Schneider PH.D.1, Hubert B. Fluckiger M.S.1, and J. Damon Manes M.S.1

1 Department of Nutritional Research, Mead Johnson Research Center, Evansville, Indiana 47721

Milk-substitute formulas have been implicated in hypoprothrombinemia in infants and the Committee on Nutrition, AAP, has recommended that those low in vitamin K be supplemented with vitamin K1. A recently developed chromatographic procedure was used to survey the amount of vitamin K1 in commercially available infant formula products. Milk-substitute formulas containing soy oil provided appreciable vitamin K, i.e., 79 to 118µg/liter (as fed), even without vitamin K1 added. Formulas to which vitamin K1 have been added contain from 118 to 256µg/liter. Milk-based formulas contain from 19 to 69µg/liter (depending on the type of oil used), but these have not been implicated in hypoprothrombinemia. According to chick bioassay, vitamin K1 added to infant formula products is biologically available.