PEDIATRICS Vol. 53 No. 2 February 1974, pp. 257-263
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Forman, B. H.
Right arrow Articles by Genel, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Forman, B. H.
Right arrow Articles by Genel, M.

Management of Juvenile Diabetes Mellitus: Usefulness of 24-Hour Fractional Quantitative Urine Glucose

Barr H. Forman M.D.1, Paul S. Goldstein M.D.1, and Myron Genel M.D.1

1 Division of Pediatric Endocrinology, Department of Pediatrics, Yale University School of Medicine and Yale-New Haven Hospital, New Haven, Connecticut

The use of quantitative urine glucose determinations permits accurate assessment of glucose homeostasis in diabetic children. Four specimens from a representative 24-hour period are collected, generally from 8 AM to noon, noon to 4 PM, 4 PM to 8 PM, and 8 PM to 8 AM and measured for total glucose excreted. When performed on an ambulatory basis, this test best reflects actual conditions the child faces each day and takes into account time, dose and type of insulin adminstered as well as diet, activity and stress. The test is inexpensive, easily performed and allows the physician to make rational changes in therapy. Children are usually cooperative and can understand what the actual amount of glucose spilled represents in terms of calories lost and total control. In those children in whom increases in NPH would be made to achieve better nighttime coverage, afternoon hypoglycemia can be prevented by changing to a combination of semilente and ultralente insulins without fear of long-acting insulin effect.