PEDIATRICS Vol. 53 No. 1 January 1974, pp. 112-114
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Loss of Limb Following Intravenous Diazepam

Sanford Schneider M.D.1 and John W. Mace M.D.2

1 Departments of Pediatrics and Neurology, Loma Linda, California 92354
2 Department of Pediatrics, Loma Linda University School of Medicine, Loma Linda, California 92354

Since its introduction for the control of status epilepticus in 1965, parenterally administered diazepam has proven to be extremely effective in halting prolonged seizure activity. Reported side effects have been minimal and usually not associated with significant morbidity. However, apnea, bradycardia, hypotension, cardiac arrest, and conversion of atypical spike and wave status epilepticus to graudmal status have been reported. Additionally, thrombophlebitis following intravenous administration has been associated with diazepam. Langdon et al. recently stated that 3.5% of patients receiving diazepam intravenously Prior to esophagogastroscopy developed thrombophlebitis. In several patients venous thrombosis was marked and tender cords were palpable many months after injection.