PEDIATRICS Vol. 52 No. 5 November 1973, pp. 680-691
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Balfour, H. H.
Right arrow Articles by Quie, P. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Balfour, H. H., Jr.
Right arrow Articles by Quie, P. G.

CALIFORNIA ARBOVIRUS (LA CROSSE) INFECTIONS

I. Clinical and Laboratory Findings in 66 Children With Meningoencephalitis

Henry H. Balfour Jr. M.D.1, Robert A. Siem Ph.D.1, Henry Bauer Ph.D.1, and Paul G. Quie M.D.1

1 Departments of Laboratory Medicine and Pediatrics, University of Minnesota Medical School, and the Division of Medical Laboratories, Minnesota Department of Health, Minneapolis, Minnesota

California encephalitis (CE) has been a significant cause of morbidity in Minnesota, accounting for 6.4% of all laboratory-documented cases of meningoencephalitis during the summers of 1967 through 1972. CE occurred in 66 children aged 6 months to 17 years. All patients were from rural or suburban areas. A mild and a severe clinical form of CE were defined with the severe form becoming more prevalent during the last two years. Focal neurologic findings were present in 16% of patients and localized abnormalities were seen in 40% of EEGs and brain scans. All patients survived but 15% had sequelae. Comparative neutralization and immunodlifusion tests indicated that La Crosse was the subtype responsible for CE in all patients appropriately studied. Since the diagnosis of CE depends on serology, antibody responses in patients during the acute illness and for two years thereafter are described. The clinical features of CE are contrasted with those of herpesvirus, mumps, and enteroviral meningoencephalitis.

Submitted on April 11, 1973
Accepted on June 4, 1973




This article has been cited by other articles:


Home page
 J Child NeurolHome page
E. C. de los Reyes, J. E. McJunkin, T. A. Glauser, M. Tomsho, and J. O'Neal
Periodic Lateralized Epileptiform Discharges in La Crosse Encephalitis, a Worrisome Subgroup: Clinical Presentation, Electroencephalogram (EEG) Patterns, and Long-Term Neurologic Outcome
J Child Neurol, February 1, 2008; 23(2): 167 - 172.
[Abstract] [PDF]

Home page
 Am J Trop Med HygHome page
J. T. UTZ, C. S. APPERSON, J. N. MACCORMACK, M. SALYERS, E. J. DIETZ, and J. T. MCPHERSON
ECONOMIC AND SOCIAL IMPACTS OF LA CROSSE ENCEPHALITIS IN WESTERN NORTH CAROLINA
Am J Trop Med Hyg, November 1, 2003; 69(5): 509 - 518.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
J. E. McJunkin, E. C. de los Reyes, J. E. Irazuzta, M. J. Caceres, R. R. Khan, L. L. Minnich, K. D. Fu, G. D. Lovett, T. Tsai, and A. Thompson
La Crosse Encephalitis in Children
N. Engl. J. Med., March 15, 2001; 344(11): 801 - 807.
[Abstract] [Full Text] [PDF]

Home page
 J Child NeurolHome page
R. S. Rust, W. H. Thompson, C. G. Matthews, B. J. Beaty, and R. W.M. Chun
Topical Review: La Crosse and Other Forms of California Encephalitis
J Child Neurol, January 1, 1999; 14(1): 1 - 14.
[Abstract] [PDF]

Home page
 PediatricsHome page
J. E. McJunkin, R. Khan, E. C. de los Reyes, D. L. Parsons, L. L. Minnich, R. G. Ashley, and T. F. Tsai
Treatment of Severe La Crosse Encephalitis With Intravenous Ribavirin Following Diagnosis by Brain Biopsy
Pediatrics, February 1, 1997; 99(2): 261 - 261.
[Full Text] [PDF]