PEDIATRICS Vol. 52 No. 2 August 1973, pp. 206-212
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FACTORS AFFECTING THE DEVELOPMENT OF SERUM IMMUNOGLOBULIN LEVELS IN INFANTS

Vlasta Vlahovicacute Ph.D.1, Tihomir Rede M.D.1, Otmar Beleznay M.D.1, Danko Pavecaronsicacute M.D.1, and Viscaronnja Raccaronki B.C.1

1 Pediatric Clinic and the Obstetrics and Gynecology Clinic, Medical School of Rijeka, University of Zagreb; and the Children's Hospital Kantrida, Rijeka, Yugoslavia

The humoral immunological status of the newborn is recognized as a combination of (1) immune globulin G derived from the mother and (2) competence for developing active immunity. To these current concepts, the data in the present study add indications that the level of transplacentally acquired IgG may play a role in controlling the time of onset of the infant's own IgG production. Increases of IgG levels occurred much later in infants born with normal adult levels of serum IgG than in infants born with relatively low serum IgG concentrations.

Submitted on August 10, 1972
Accepted on March 7, 1973