PEDIATRICS Vol. 52 No. 2 August 1973, pp. 161-168
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OBSERVATIONS ON THE RELATIONSHIP BETWEEN DURATION OF RUPTURE OF THE MEMBRANES AND THE DEVELOPMENT OF IDIOPATHIC RESPIRATORY DISTRESS SYNDROME

Jing Ja Yoon M.D.1 and Rita G. Harper M.D.1

1 Department of Pediatrics, State University Downstate Medical Center, Brooklyn, New York

Retrospective analysis of 211 premature infants between 1,001 and 2,165 gm at birth revealed a decreased incidence of idiopathic respiratory distress syndrome in infants with rupture of the membranes more than 24 hours prior to delivery. Infants with factors which are known to predispose to idiopathic respiratory distress syndrome (maternal hemorrhage, maternal diabetes, fetal asphyxia, twin B, history of a sibling with idiopathic respiratory distress syndrome and cesarean section) were then eliminated. One hundred and twenty infants remained. Infants with rupture of the membranes more than 24 hours prior to delivery had a significantly lower incidence of idiopathic respiratory distress syndrome when compared with infants with rupture of the membranes less than 12 hours prior to delivery (P<0.05).

From this study it appears that rupture of the membranes for more than 24 hours prior to delivery protects against the development of idiopathic respiratory distress syndrome.

Submitted on April 24, 1972
Accepted on March 29, 1973




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