PEDIATRICS Vol. 51 No. 4 April 1973, pp. 651-654
This Article
Right arrow Full Text (PDF)
Right arrow P3Rs: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when P3Rs are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Siegel, S. R.
Right arrow Articles by Oh, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Siegel, S. R.
Right arrow Articles by Oh, W.

THE EFFECTS OF RAPID INFUSION OF HYPERTONIC SODIUM BICARBONATE IN INFANTS WITH RESPIRATORY DISTRESS

Sharon R. Siegel M.D.1, Dale L. Phelps M.D.1, Rosemary D. Leake M.D.1, and William Oh M.D.1

1 Department of Pediatrics, Harbor General Hospital, Torrance, and St. Mary's Long Beach Hospital, Long Beach, California/UCLA School of Medicine

The effects of rapid intravascular infusion of 0.9 M sodium bicarbonate were evaluated in 18 full-term and premature newborn infants who had predominant metabolic acidosis associated with respiratory distress. During the 30-minute postinfusion period, the hematocrit fell at three minutes from 50% to 45% (p = < .001), and returned to 46.5% at 30 minutes (p = < .02); the serum sodium rose from 135 mEq/liter to 141 mEq/liter (p = < .05) at three minutes and then returned to 136 mEq/liter at 30 minutes; the osmolality increased from 278 mOsm/liter to 287 mOsm/liter at three minutes (p = < .001) and returned to 281 mOsm/liter at 30 minutes; and the arterial blood pressure rose from a baseline of 46.8 mm Hg to 48 mm Hg at One minute (p = < .05), dropped below the baseline at 15 minutes (p = < .05), and rose almost to the baseline at 30 minutes. These results suggest that rapid intravascular infusion of hypertonic sodium bicarbonate may lead to an increase in intravascular volume. No significant clinical symptoms related to central nervous system insults were observed.

Submitted on September 22, 1972
Accepted on January 3, 1973




This article has been cited by other articles:


Home page
 PediatricsHome page
P. Carteaux, H. Cohen, J. Check, J. George, P. McKinley, W. Lewis, P. Hegwood, J. M. Whitfield, D. McLendon, S. Okuno-Jones, et al.
Evaluation and Development of Potentially Better Practices for the Prevention of Brain Hemorrhage and Ischemic Brain Injury in Very Low Birth Weight Infants
Pediatrics, April 1, 2003; 111(4): e489 - 496.
[Abstract] [Full Text] [PDF]