PEDIATRICS Vol. 51 No. 2 February 1973, pp. 188-191
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NONOPERATIVE DIAGNOSIS OF HIRSCHSPRUNG'S DISEASE IN NEONATES

Hiroshi Suzuki M.D.1, John J. White M.D., C.M.1, Mohamed El Shafle M.D.1, Issam J. Shaker M.D.1, J. Alex Haller Jr. M.D.1, and Louise Schnaufer M.D.1

1 Division of Pediatric Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, and the Second Department of Surgery, Tohuku University School of Medicine, Sendai, Japan

Twenty-eight neonates who presented with symptoms suggestive of Hirschsprung's disease have been studied by the technique of anorectal manometry using newly developed, miniaturized instrumentation. Eight infants have demonstrated the typical lack of relaxation of the smoothmuscle internal anorectal sphincter characteristic of Hirschsprung's disease. Aganglionosis has been demonstrated histologically in all eight, including two prematures; the remainder have not developed any sign of Hirschsprung's disease. This miniaturized technique of anorectal manometry may provide an accurate, simple, and atraumatic method for identifying Hirschsprung's disease in the newborn infant.

Submitted on September 29, 1972
Accepted on October 13, 1972