PEDIATRICS Vol. 51 No. 1 January 1973, pp. 91-96
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PULMONARY HYPOPLASIA: A MORPHOMETRIC STUDY OF THE LUNGS OF INFANTS WITH DIAPHRAGMATIC HERNIA, ANENCEPHALY, AND RENAL MALFORMATIONS

Frank R. Reale M.D.1 and John R. Esterly M.D.1

1 Department of Pathology and of Obstetrics and Gynecology, The University of Chicago, and The Laboratory of Pathology of the Chicago Lying-in Hospital, Chicago, Illinois

The type and severity of underdevelopment of the lungs in infants with three congenital malformations were studied in histologic sections. The mean lung weight:body weight ratios were significantly decreased in infants who had diaphragmatic hernia, anencephaly, and a group of renal anomalies. Radial alveolar counts of the distal airways were also significantly decreased, although the range for each group included normal values. The data suggest that decreased proximal branching is a component of pulmonary hypoplasia in these malformations, because in the majority of infants, the decrease in lung weight was greater than could be explained by the decrease in the number of peripheral air spaces. No apparent qualitative differences in the type of hypoplasia were found in these infants; changes in the histologic appearance were correlated with severity and were independent of the type of associated malformation.

Submitted on June 12, 1972
Accepted on August 8, 1972




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