PEDIATRICS Vol. 51 No. 1 January 1973, pp. 122-124
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Intracranial Hemorrhage and Subsequent Communicating Hydrocephalus in a Neonate With Classical Hemophilia

James W. McCarthy M.D.1 and Larry L. Coble M.D.1

1 Department of Pediatrics U.S. Army General Hospital Fort Gordon, Georgia 30905

Quick1 states that spontaneous intracranial hemorrhage is less common in hemophilia than in other clotting disorders, though others2-3 have shown it to occur in as high as 10% to 13% of all cases of hemophilia. However, intracranial hemorrhage is an exceedingly rare occurrence in the neonate with hemophilia.4-5 Silverstein's review of 31 reported cases of proven hemophilia with intracranial hemorrhages revealed only one case in the neonatal period. The advent of readily available and definitive laboratory procedures for the prompt diagnosis of hemophilia coupled with the development of factor VIII concentrates allows for the aggressive treatment of intracranial hemorrhages and their complications.




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B.P. Sachs, D. Acker, R. Tuomala, and E. Brown
The Incidence of Symptomatic Intracranial Hemorrhage in Term Appropriate-for-gestation-age Infants
Clinical Pediatrics, July 1, 1987; 26(7): 355 - 358.
[Abstract] [PDF]