PEDIATRICS Vol. 50 No. 5 November 1972, pp. 812-814
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Serum 5’-Nucleotidase in Neonatal Hepatitis and Biliary Atresia: Preliminary Observations

C. Y. YEUNG M.B., B.S., M.R.C.P., D.C.H.1

1 Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada

This study is in agreement with the observation that the serum 5’ nucleotidase level is related to the degree of bile duct proliferation in hepatobiliary disease. In infants with congenital extrahepatic biliary atresia, where ductal proliferation is a feature, the enzyme levels are markedly raised and are significantly different from those with neonatal hepatitis. Such finding is of diagnostic value in differentiating between the two conditions.