PEDIATRICS Vol. 50 No. 5 November 1972, pp. 712-717
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ATYPICAL MEASLES IN CHILDREN PREVIOUSLY IMMUNIZED WITH ATTENUATED MEASLES VIRUS VACCINES

James D. Cherry M.D.1, Ralph D. Feigin M.D.1, Louis A. Lobes Jr. M.D.1, and Penelope G. Shackelford M.D.1

1 Department of Pediatrics, St. Louis University School of Medicine, and the Infectious Disease Unit, Bidwell Research Center, Cardinal Glennon Memorial Hospital for Children, and the Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine and the Division of Infectious Diseases, St. Louis Children's Hospital and the St. Louis City Division of Health

During the winter and spring of 1970 to 1971, an epidemic of measles occurred in the St. Louis area. During a study of this epidemic, 12 children had clinical illnesses suggesting the "atypical measles" syndrome, but six of these children had received only live attenauted measles vaccines. The illnesses in these six children were qualitatively similar to those in the six children who had been immunized with killed measles vaccines, but they were quantitatively less severe. Acute-phase measles HAI antibody titers in the recipients of live vaccines were greater than those of killed vaccine recipients, whereas the converse was true of the convalescent-phase serum titers.

Submitted on March 20, 1972
Accepted on July 3, 1972




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S. Vessal and L. P. Kravis
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