PEDIATRICS Vol. 50 No. 1 July 1972, pp. 92-99
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BODY GROWTH IN COOLEY'S ANEMIA (HOMOZYGOUS BETA-THALASSEMIA) WITH A CORRELATIVE STUDY AS TO OTHER ASPECTS OF THE ILLNESS IN 138 CASES

John Logothetis M.D.1, Ruth B. Loewenson Ph.D.1, Olga Augoustaki M.D.1, Joanna Economidou M.D.1, and Mathios Constantoulakis M.D.1

1 Department of Neurology, University of Minnesota Medical School, Minneapolis; and the Research Hematology Section of the Hellenic Red Cross, Athens, Greece

A cross-sectional study of 138 patients with Cooley's anemia, from 2 to 28 years of age, demonstrated retardation in height and weight except for children under the age of 4 years. Head circumference showed no consistent deviation from normal. A tendency was found for both height and weight to fall further behind the normal average with increasing age during the growing years. The degree of retardation appeared of significant magnitude only by the age of 9 to 10 years which is probably the age when the retardation in growth became noticeable to the observer. The degree of anemia showed only slight correlation with the degree of retardation in height and weight. Systemic abnormalities, however, that reflect the severity of the illness appeared to parallel the retardation of growth.

Submitted on June 3, 1971
Accepted on November 3, 1971




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M. Constantoulakis, G. Panagopoulos, and O. Augoustaki
Stature and Longitudinal Growth in Thalassemia Major: A Study of 229 Greek Patients
Clinical Pediatrics, April 1, 1975; 14(4): 355 - 368.
[Abstract] [PDF]