PEDIATRICS Vol. 5 No. 1 January 1950, pp. 38-44
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PASSIVE INTRAPERITONEAL MOUSE PROTECTION TEST IN A STUDY OF IMMUNE RESPONSE TO H. PERTUSSIS VACCINATION

JOHN P. MCGOVERN M.D.1

1 The Departments of Pediatrics and Bacteriology, Duke University School of Medicine and Duke Hospital, Durham, N.C.

A passive mouse protection test and its use in testing sera from infants given a course of phase I pertussis vaccine is described. Infants 3 to 6 months of age consistently developed mouse protective antibodies following immunization with a phase I H. pertussis vaccine. Agglutinating antibodies did not develop consistently in these infants and the agglutinin titer did not closely parallel the values obtained by the mouse protection test.

Submitted on March 10, 1949