PEDIATRICS Vol. 49 No. 6 June 1972, pp. 928
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schiff, D.
Right arrow Articles by Stern, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schiff, D.
Right arrow Articles by Stern, L.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Diazepam (Valium) for Neonatal Narcotic Withdrawal: A Question of Safety

David Schiff M.D., Ph.D.1, George Chan B.Sc., M.Sc.1, and Leo Stern M.D.1

1 McGill University-Montreal Children's Hospital, Research Institute, Department of Newborn Medicine, Montreal Children's Hospital, 2300 Tupper Street, Montreal 108, Quebec, Canada

While we do not dispute the efficacy of diazepam (Valium) in the management of the neonatal narcotic withdrawal syndrome, we cannot agree with the statement made by the authors regarding the safety of the injectable preparation of diazepam. Like caffeine sodium benzoate, the injectable preparation of diazepam is capable of displacing bilirubin from its albumin-binding site, a property which in the case of sulfisoxazole, has resulted in the occurrence of kernicterus at low serum levels of bilirubin. This property lies not with the therapeutically active diazepam component, but with the buffer preservative which contains sodium benzoate.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 PediatricsHome page
Committee on Drugs
Neonatal Drug Withdrawal.
Pediatrics, June 1, 1998; 101(6): 1079 - 1079.
[Abstract] [Full Text] [PDF]