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PEDIATRICS Vol. 49 No. 2 February 1972, pp. 314
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Use of Diazepam in Neonatal Narcotic Withdrawal Syndrome

Marvin Rosen M.D.1

1 Department of Pediatrics, Darnall Army Hospital, Fort Hood, Texas 76544

I read with interest and concern the recent article1 by Drs. Nathenson, Golden, and Litt concerning the use of diazepam in the neonatal narcotic withdrawal syndrome. Another recent article in your journal2 points out that diazepam for parental use contains sodium benzoate. Sodium benzoate has the capacity to interfere with bilirubin-albumin binding. There are many other good drugs that the physician may use (paregoric, chlorpromazine, phenobarbital3,4) without theoretically increasing the risk of kernicterus, and perhaps the use of diazepam in the neonatal period for narcotic withdrawal would best be avoided, at least until further information is available.


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