PEDIATRICS Vol. 49 No. 1 January 1972, pp. 71-79
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FAMILIAL SELECTIVE IgA DEFICIENCY

Patricia A. Nell M.D.1, Arthur J. Ammann M.D.1, Richard Hong M.D.1, and E. Richard Stiehm M.D.1

1 Departments of Pediatrics, University of Wisconsin Medical Center, Madison, Wisconsin, and the University of California School of Medicine, Los Angeles, California

Thirteen subjects with selective IgA deficiency were obtained from five separate families. In three families an autosomal recessive inheritance was apparent while an autosomal dominant inheritance appeared very likely in the two remaining families.

An increased incidence of quantitative defects in immunoglobulin synthesis was seen in addition to evidence of abnormal antibody production and increased autoantibody formation.

Submitted on March 1, 1971
Accepted on June 25, 1971