PEDIATRICS Vol. 48 No. 5 November 1971, pp. 815-816
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"Acne Vaccinatum"—A Complication of Smallpox Vaccination

Barton S. Schmitt M.D.1 and Melvin I. Marks M.D.1

1 Department of Pediatrics, University of Colorado, Medical Center, Denver, Colorado 80220

Although most textbook and committee recommendations on immunizations mention eczema and other more acute dermatitides as contra-indications to vaccination, no specific reference could be found regarding the significance of acne vulgaris.1,2 We have recently observed a serious complication of primary smallpox vaccination in a patient with acne vulgaris.

Case Report

Ten days after receiving a primary smallpox vaccination, a 16-year-old male was seen for a 2 x 2 x 2 cm tender node in his left axilla. He was afebrile and had a primary pustular vaccination reaction of the skin over the left deltoid muscle as well as left axillary lymphadenopathy.




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