PEDIATRICS Vol. 48 No. 5 November 1971, pp. 777-781
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ECG CHANGES IN FATAL IMIPRAMINE (TOFRANIL) INTOXICATION

Jean-Claude Fouron M.D., F.R.C.P.(C)1 and Raymond Chicoine M.D.1

1 Department of Pediatrics, Maisonneuve Hospital, Montreal, Quebec, Canada

A case of poisoning with imipramine (Tofranil) has been followed by serial ECG tracings in an 11-month-old boy. Profound alteration of his myocardial function has been observed during the first 18 hours following absorption of the drug; these cardiovascular perturbations lead to irreversible cerebral damage.

Because of the atropine-like effect of the drug and the report of alteration in the ECG tracing of adult patients under imipramine therapy, it is advised that all children under such therapy be checked with an occasional ECG for possible change in myocardial function.

Submitted on September 21, 1970
Accepted on March 31, 1971




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